Biomedical Engineering Reference
In-Depth Information
400
(a) Free IGF-I
300
c
1
f
= 20 ng/mL,
c
2
f
= 0 ng/mL
c
1
f
= 20 ng/mL,
c
2
f
= 200 ng/mL
200
100
0
0
1
2
3
4
5
Time (h)
400
(b) Bound IGF-I
300
c
1
f
= 20 ng/mL,
c
2
f
= 0 ng/mL
c
1
f
= 20 ng/mL,
c
2
f
= 200 ng/mL
200
100
0
0
1
2
3
4
5
Time (h)
FIGURE 11.15
Percent increase in time-dependent, free, and bound IGF-I uptake in normal
cartilage condition, in the absence (i.e.,
c
f
10
= 20 ng/mL,
c
f
20
= 0 ng/mL) or in
the presence of IGF-II competition (i.e.,
c
f
10
= 20 ng/mL,
c
f
20
= 200 ng/mL),
after 5 h 0.1 Hz at 6% strain cyclic deformation.
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