Biomedical Engineering Reference
In-Depth Information
1.5
(a) Free IGF-I
c
1
f
= 10 nM,
c
2
f
= 1 nM
c
1
f
= 1 nM,
c
2
f
= 1 nM
1
c
1
f
= 0.1 nM,
c
2
f
= 1 nM
0.5
0
0
10
20
30
40
50
60
Time (h)
70
80
90
100
110
120
130
1.5
(b) Complexed IGF-I
c
1
f
= 0.1 nM,
c
2
f
= 1 nM
c
1
f
= 1 nM,
c
2
f
= 1 nM
c
1
f
= 10 nM,
c
2
f
= 1 nM
10
5
0
0
10
20
30
40
50
60
Time (h)
70
80
90
100
110
120
FIGURE 11.14
Comparison of time-dependent average IGF-I uptake ratio in the cartilage
under various boundary IGF-I concentrations (
c
b
BP
1
= 45 nM;
c
b
BP
2
= 101
nM). (a) Free IGF-I; (b) Bound IGF-I.
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