Biomedical Engineering Reference
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2.5
(a) Free diffusion with binding
2.0
1.5
1.0
0.5
0.0
0
0.2
0.4
Radial distance from the center of cartilage (mm)
0.6
0.8
1
1.2
(b) Free diffusion without binding
1.0
0.8
0.6
0.4
0.2
0.0
0
0.2
0.4
Radial distance from the center of cartilage (mm)
0.6
0.8
1
FIGURE 11.7
Total solute uptake ratio (
R
u
) as a function of radial distance from center of
cartilage undergoing free diffusion, with or without consideration of binding
effects (
c
I
0
= 40 nM). Time between each curve is 5 h.
role that binding proteins play in modifying this cyclic-loading enhanced trans-
port. When IGF-I interaction with IGFBPs are included in the model we see
that the enhancement of the free IGF-I is greater and for a longer time period
than seen in the equivalent model which ignored IGFBPs (i.e., Figure 11.11).
Therefore, IGFBPs appear to provide a mechanism to enhance the transport
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