Biomedical Engineering Reference
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refrigerator and transfused within 72 hours of collection), which was collected
after lower uterine cesarean section (LUCS), and transfused to 16 consenting
HIV-positive patients (12 cases had full-blown AIDS) with anemia and emacia-
tion. Apart from the correction of anemia, there was also defi nite improvement in
the energy and fatigue levels in individuals with HIV, that is, physical functioning,
a sense of well-being and weight gain from two to fi ve pounds, within three to ten
months of the commencement of transfusion. There was also an immediate rise in
CD34 levels of peripheral blood in the HLA-randomized host after transfusion,
without any clinical graft versus host reaction [Bhattacharya (36)].
Another study was conducted, comprising 106 units (48 ml-148 ml mean
81 ml +/
−
6.6 ml SD, median 82 ml, mean packed cell volume 49.4 +/
−
3.1 SD, mean
percent hemoglobin concentration 16.3 g/dl +/
1.7 g/dl SD) of ABO matched,
HLA randomized placental umbilical cord whole blood transfusion (taken from
consenting mothers after LUCS) to 21 informed consenting patients with tuber-
culosis and anemia (from 1 April 1999 to August 2005) who had plasma hemoglo-
bin of 8 g/dl percent or less. The patients received two to twenty-one units of
freshly collected blood without encountering any clinical, immunological or non-
immunological reactions. Three days after completion of the placental umbilical
cord blood transfusion, the peripheral blood hematopoietic stem cell (CD34)
estimation revealed a rise from the pretransfusion base level (.09%), varying
from 2.99% to 33%, which returned to base level in 66.66% at the three-month
CD34 re-estimation, without provoking any clinical graft vs. host reaction in any
of the patients [Bhattacharya (37)].
In another report on the experience of combating anemia in the background
of autoimmune diseases like rheumatoid arthritis, 78 units (42 ml-136 ml mean
80.6 ml +/
−
−
3.6 ml SD, median 82.4 ml, mean packed cell volume 48.2 +/
−
2.1 SD,
mean percent hemoglobin concentration 16.4 g/dl +/
1.5 g/dl SD) of placental
umbilical cord whole blood was transfused (from 1 April 1999 to 31 March 2005)
to 28 informed, consenting patients with advanced rheumatoid arthritis who had
plasma hemoglobin of 8 g/dl or less. Three days after completion of the transfu-
sion of placental umbilical cord blood, the peripheral blood hematopoietic stem
cell (CD34) estimation revealed a rise from the pretransfusion base level (.09%),
varying from 2.03 to 23% [Bhattacharya (38)].
The author has also reported the experience of 74 units (50 ml-146 ml mean,
86 ml +/
−
−
7.6 ml SD, median 80 ml, mean packed cell volume 48 +/
−
4.1 SD, mean
percent hemoglobin concentration 16.2 g/dl +/
1.8 g/dl) of placental umbilical
cord whole blood collection (from 1 April 1999 to 31 August 2006) transfused to
16 informed, consenting patients suffering from leprosy with plasma hemoglobin
8 g/dl or less. Fifteen males and one female, aged 12 to 72 years (mean 48.4 years)
participated in this trial, of which fi ve cases were having pausibacillary-type (PB)
infection and 11 cases were suffering from multibacillary-type (MB) infection.
Seven days after completion of the placental umbilical cord blood transfusion, the
peripheral blood hematopoietic stem cell (CD34) estimation revealed a rise from
the pretransfusion base level (.09%), varying from 3.6% to 16.2%, in 75% of
the cases, without provoking any clinical graft versus host reaction in any of the
−
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