Biomedical Engineering Reference
In-Depth Information
2.5
2
1.5
1
Series 1
Series 2
0.5
0
1
3579
Number of randomly selected patients
11
13
15
17
19
Figure 19.6.
Graphical impact of 2 units of cord blood transfusion on the host's bilirubin level
as seen after 72 hours. Source: Malar J. 2006; 5: 20.
going lower uterine cesarean section. Here, too, no case of immunological or non-
immunological reaction was encountered [Bhattacharya (33)].
In another extensive study conducted between April 1, 1999 and 2005, the
investigator transfused cord blood in 129 informed consenting patients (54 men
and 75 women). Patient ages varied from two years to 86 years. Seventy-three
patients (56.58%) suffered from advanced cancer and 56 (43.42%) patients had
other diseases like ankylosing spondylitis, lupus erythematosus, rheumatoid
arthritis, aplastic anemia, and thalassemia major. There was no transfusion related
problem in this series as well [Bhattacharya (34)].
In a recent article published in
Med Hypotheses
in 2007, the authors,
Chaudhuri A, Hollands P, and Bhattacharya N, have discussed the immense
potentialities of cord blood use in acute ischaemic stroke to prevent neurological
damages [Chaudhuri, Hollands, and Bhattacharya, (35)].
19.8 SPECIAL PROPERTIES OF CORD BLOOD TRANSFUSION
Cord blood use and its effect on the host system have several dimensions. One
signifi cant observation from the studies mentioned is that transfusion of hypoan-
tigenic cord blood in a non-myloablated recipient has a transplant impact on the
host system, which raises a serious question regarding the necessity of myeloabla-
tion and/or immunosupression on donor recipient HLA mismatch.
The author noted this impact in several cases. In a recently published article,
the author reported the experience of transfusion of 123 units of placental umbil-
ical cord whole blood (62 ml - 154 ml mean 85 ml +/
−
8.4 ml SD, median 82 ml, mean
packed cell volume 48.8 +/
−
4.2 SD, mean percent hemoglobin concentration
16.3 g/dl +/
−
1.6 g/dl SD; after collection the blood was immediately preserved in a
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