Biomedical Engineering Reference
In-Depth Information
Fig. 2.10
Comparison of the optical intensity across (
a
) 15 % and (
b
) 20 % gel lanes, for silica
particles, between non-gradient (
black
and
red
) and gradient (
blue
) coronas; the
x
-axis corresponds
to the run length, normalized according to how far different proteins in the molecular weight
standards lane had moved in each respective gel; the
y
-axis is the normalized intensity of the lanes
(adapted with permission from [
35
])
Fig. 2.11
Schematic representation of the importance of NP trafficking on catching
apolipoproteins in its corona composition (adapted with permission from [
35
])
intravenous, intraosseous, intralumbar, and inhalation), which contain different
protein compositions and concentrations. For example, the nanoparticle will first
“see” the lung cell barrier in the case of being inhalated. Thus, different pathways
lead to various corona compositions. In order to show this effect, adsorption of
