Biomedical Engineering Reference
In-Depth Information
Fig. 2.2
Relative volume of the major proteins adsorbed on the surface of USPIO NP obtained
after incubation with different plasma dilutions (adapted with permission from [
18
])
Fig. 2.3
Total amounts of proteins adsorbed on the surface of the USPIO NP after incubation with
different plasma dilutions (adapted with permission from [
18
])
previously adsorbed proteins by other proteins possessing a higher affinity to the
particle surface can be determined. Compared to other nanomaterial-based drug
delivery systems, similar results have been reported singularly for o/w nanoemulsions,
whereas the existence of a Vroman effect has been observed on the surface of
polymeric model particles. There are also differences in the protein adsorption patterns
received from USPIO compared to nanoemulsions. Immunoglobulins are the domi-
nant protein group during all steps of plasma protein adsorption onto USPIO particles.
An increasing amount of fibrinogen with prolonged incubation times has been
observed (Figs.
2.2
and
2.3
). Low amounts of adsorbed dysopsonic proteins, such as
apolipoproteins and albumin, support this prediction. Over a certain period of time,
