Biomedical Engineering Reference
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Figure 42.5.
Chemiluminescent nanoparticles for the detection of hydro-
gen peroxide.
presence of hydrogen peroxide was almost 100 times higher that
with either hydroxyl radicals or superoxide. The capability of
imaging of
in vivo
hydrogen peroxide was performed by injecting
peroxalatenanoparticlesintotheintraperitonealcavityofmiceafter
the induction of inflammation using lipopolysaccharide (LPS).
Figure42.7showsimageschemiluminescenceemittedfrommice
treated with peroxalate nanoparticles.
After the treatment of peroxalate nanoparticles, mice treated
with LPS exhibited two times higher chemiluminescence intensity
than mice treated with saline. The results clearly demonstrated
thatperoxalatenanoparticlescomposedofperoxalatepolymersand
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