NOVEL FABRICATION AND CHARACTERIZATION OF PORE-SIZE-GRADIENT SCAFFOLDS BY A CENTRIFUGATION TECHNIQUE - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 599

Figure 30.7. Normalizedloaddisplacementcurvesofcylindricalchitosan
scaffold sections along the longitudinal direction (Ref. 22).

For PCL scaffolds, heat treatment near the PCL melting temper-
ature (59 ◦ C) was conducted during the scaffold fabrication for fib-
ril bonding between adjacent PCL by slight melting, leading to the
prevention of the disentanglement of fibrous structures and to the
improvement ofmechanical strength ofthe scaffold.
As shown in Fig.30.8a, the mechanical property of the scaffold
increased by the heat treatment (i.e., fibril-bonding process). The
dimension or pore structure of the scaffold was little affected by the

Figure 30.8. NormalizedloaddisplacementcurvesofcylindricalPCLscaf-
fold sections. (a) Comparison of scaffold sections with/without heat treat-
ment at the position of 2.0 2.5 cm and (b) heat-treated scaffold sections

along the longitudinaldirection (Ref. 28).

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