Biomedical Engineering Reference
In-Depth Information
celldeliverywithhighloadingande
ciencytospecificsites.There-
fore, the scaffold must provide a suitable substrate for cell attach-
ment, cell proliferation, differentiated function, and cell migration.
The prerequisite physicochemical properties of scaffolds are (i) to
support and deliver for cells, (ii) to induce and differentiate and
to be a conduit for tissue growth, (iii) to target the cell adhesion
substrate, and (iv) to stimulate a cellular response. Other proper-
ties include (i) a wound-healing barrier, (ii) biocompatibility and
biodegradability,(iii)relativeeaseofprocessabilityandmalleability
into desired shapes, (iv) high porosity with a large surface/volume,
(v)mechanicalstrengthanddimensionalstability,(vi)sterilizability,
O
O
CH
2
CH
2
n
OCH
2
CH
2
O
C
C
1
n
6
CH
2
CF
2
n
O
O
2
OCH
2
CH
2
CH
2
CH
2
O
C
C
n
7
CF
2
CF
2
n
3
CH
3
CH
3
CH
2
CH
2
CH
2
O
CH
2
C
O
CH
2
O
n
C
O
CH
3
O
4
CH
2
OH
n
CH CH
2
OH
8
n
n
9
5
N
n
11
CH
2
C
H
C
NH
CH
H
3
C H
3
O
O
O
CH
3
N
N
R
Si O
CH
3
O
O
n
n
n
12
13
10
(A)
(A) Synthetic nondegradable polymers: 1. polyethylene, 2. poly(vinylidene
fluoride), 3. polytetrafluoroethylene, 4. poly(ethylene oxide), 5. poly(vinyl
alcohol), 6. poly(ethyleneterephthalate), 7. poly(butyleneterethphalate), 8.
poly(methylmethacrylate), 9. poly(hydroxymethylmetacrylate), 10. poly(N-
isopropylacrylamide), 11. polypyrrole, 12. poly(dimethyl siloxane), and
13. polyimides.
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