Biomedical Engineering Reference
In-Depth Information
Figure 9.8.
Sulfation of HA.
16
Figure 9.9.
Acrylation of HA with acylchlorides.
36
reducedbothplateletadhesionandthrombosisformation.Sulfation
was obtained by chemically grafting sulfur trioxide pyridine to the
hydroxyl group in HA, thusincreasing anioniccharges of HA.
9.3.5
Acrylates
Graftings of unsaturation domains to HA have been tried to func-
tionalize for further chemical reactions through either photochem-
istry with an adequate initiator or Michael-type addition reactions
without an initiator. Hydroxyl groups of HA have been employed
to produce their reactions with acryloyl chlorides (Fig. 9.9).
36
These acrylate end groups have been employed for further sites of
photopolymerization and Michael-type addition reactions (see the
following session).
9.4 Fabrication of Hyaluronic Acid Hydrogels
HAhasdemonstratedmanyinherentbiologicalandchemicaladvan-
tages for biomaterials applications such as hydrogels and scaffolds
for tissue engineering and carriers in drug and cell delivery system.
Hydrogels have been created by employing HA-derivatives through
manychemicalmethodssuchasbifunctionalcross-linkers,enzymes,
intra- and inter-molecular reactions, photochemical reactions,
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