Biomedical Engineering Reference
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Figure 9.5.
Functionalization of HA with primary amines and thiols via
HA-COOH.
33
Figure 9.6.
Synthesis of HA-SH.
34
,
35
Figure 9.7.
Functionalization of HA with thiolsvia HA-OH.
34
,
35
by acidifying after processing of both filtering and reducing with
reducting agents such as DTT. Further derivertization of fluroscein
was performed, grafting either flurorescein, 4-(hydroxymercuri)
benzoate, or iodoacetate to thisthiolgroup.
9.3.4
Sulfation
Molecules with sulfate groups have been grafted to HA to mimic
hemocompatibility of heparan sulfate (Fig. 9.8) by employing the
mechanisms of electrostatic repulsion of anionic charges of the
sulfate groups.
16
The anionic charges of the HA-heparan sulfates
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