Biology Reference
In-Depth Information
VSM
AT
1
R
b
arr2
Signal
transducer
EGFR
transactivation-ERK,
BAD inhibition,
"
VSM hyperplasia-
hypertrophy
Inhibition or
stimulation of
b
arr1
(atherosclerosis)
35-37
"
DNA synthesis
Adrenal
AT
1
R
b
arr1
Signal
transducer
DGK-PA-ERK-
StAR upregulation
"
Aldosterone synthesis and
secretion
Inhibition
(HF, HTN)
38,39
VSM
ET
A
R
b
arr2
Signal
transducer
ERK, p38 MAPK
"
VSM hyperplasia-
hypertrophy-cell migration
Inhibition
(atherosclerosis)
40,41
Renal
distal
tubule
V
2
R
b
arr1/2
Desensitizer N/A
#
Renal H
2
O reabsorption,
NDI, NSIAD
Inhibition
(NDI-NSIAD,
polymorphic V
2
Rs)
42,43
b
arr1
VSM
GPR109A
Signal
transducer
c
PLA
2
-AA-PGD
2
Niacin-induced vasodilation-
“flushing,”
Inhibition
(hyperlipidemia)
44
niacin efficacy
via GPR109A desensitization
#
Platelet
P2YR
b
arr1
Signal
transducer
Src-Akt-integrin
a
IIb
b
3
"
Thrombosis
Inhibition
(TE syndromes)
45
VSM
P2YR
b
arr1
Desensitizer N/A
#
Vasoconstriction-VSM
cell migration
Stimulation (HTN,
arteriosclerosis)
41,46
Continued
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