Biomedical Engineering Reference
In-Depth Information
A
B
C
Fig. 25. Biocampatible tests after 42 days. Control group (A), conventional GIC (B), and
experimental GIC (C) (100X. H.E.).
inflammatory reaction and residual dispersed cement was detected (Figure 25B), while
necrosis areas and other changes were absent. As for GII (Conventional GIC), there was a
mild to absent chronic inflammatory reaction, without foreign body giant cells or
macrophages. Some dispersed material was observed, but no necrosis areas or degenerative
changes were seen (Figure 25C).
In summary, both tested cements caused a mild to absent inflammatory response after 42
days, which is also acceptable from a biological standpoint.
3. Conclusion
Bioapplications that could provide better quality of life for humanity are desirable. It has
been demonstrated here that a series of materials prepared by sol-gel methodology
(hydrolytic and non-hydrolytic routes) present useful properties for application in biological
medium. Indeed, it was possible to obtain multifunctional materials by this methodology.
The combination of the different elements at molecular and atomic level affords potential
candidates for a variety of applications. The very interesting results obtained by us in the
present work indicate that this methodology can be applied for production of biomaterials
with potential application in several fields such as medicine, dentistry, veterinary,
engineering, chemistry, physics, and biology. Materials for use in the areas of bone implant,
restorative tooth coating, diagnosis, membrane permeability, biosensor, scaffolding, and
drug delivery can be prepared and transformed into biocompatible, bioactive, bioinducer
materials with different properties and composition, since this methodology allows for
production of materials with controlled stoichiometry and particle size.
4. Acknowledgment
The authors gratefully acknowledge the financial support of the Brazilian research funding
agencies FAPESP, CNPq, and CAPES. Profa. Dra. Isabel Salvado from Departamento de
Engenharia Cerâmica e do Vidro - CICECO - Universidade de Aveiro/Pt, Dr. Jorge V. L. Silva
do Centro da Tecnologia da Informação Renato Archer (CTI), - Campinas - SP - Brazil, Profa.
Dra. Shirley Nakagaki, Departamento de Química da Universidade Federal do Paraná - PR -
Brazil, Profa. Dra. Fernanda de C. P. Pires de Souza, Departamento de Materiais Dentários da
Universidade de São Paulo - Ribeirão Preto - SP - Brazil, and Prof. Dr. Carlos Henrique
Martins da Universidade de Franca - Franca - SP - Brazil are also acknowledged.
