Biomedical Engineering Reference
In-Depth Information
Figures 23, 24, and 25 show the biocompatible tests after 7, 21, and 42 days, respectively.
A
B
C
Fig. 23. Biocampatible tests after 7 days. Control group (A), conventional GIC (B), and
experimental GIC (C) (100X. H.E.).
In the case of the control group (CG), connective tissue with delicate fibers, highly
cellularized with fibroblasts and several blood vessels adjacent to all the analyzed faces was
observed after 7 days (Figure 23A). A mild chronic inflammatory reaction was also detected.
As for the experimental cement group (GI) (Experimental GIC), a layer of cellularized
connective tissue with moderate chronic inflammatory reaction, predominantly formed by
lymphocytes and blood vessels, was observed after 7 days. Small areas of necrosis were also
noted (Fig. 23B). Few macrophages or foreign body multinucleated giant cells were seen.
Concerning the conventional cement (GII) (Conventional GIC), an intense chronic
inflammatory reaction, associated with hyperemic blood vessels and macrophages (Figure
23C) was detected after 7 days. Necrosis area was observed close to the dispersed material.
A
B
C
Fig. 24. Biocampatible tests after 21 days. Control group (A), conventional GIC (B), and
experimental GIC (C) (100X. H.E.).
After 21 days, the CG group presented a mild chronic inflammatory reaction in this period
(Figure 24A). As for GI (Experimental GIC), there was a mild chronic inflammatory reaction,
with few lymphocytes and several fibroblasts, in the connective tissue adjacent to the open
end of the tube. Foreign body multinucleated giant cells and macrophages were not
observed (Figure 24B). In the case of GII (Conventional GIC), the connective tissue exhibited
a moderate chronic inflammatory reaction. Phagocytic activity and rare necrosis areas were
also observed (Figure 24C).
After 42 days, the CG presented no chronic inflammatory reaction (Figure 25A). Concerning
the GI group (Experimental GIC), connective tissue with mild to absent chronic
