Biology Reference
In-Depth Information
Figure 1.3, cont'd
Use of biological data to refine the limits defined by clinical incidence data
.
Remote sensing surfaces, showing temperature (
Fig. 1.5
) and aridity
(
Fig. 1.6
), and biological models were used to identify areas where extreme
temperature or aridity regimes would reduce or preclude
P. vivax
transmis-
sion. The limits of transmission are adjusted accordingly.
The effect of interventions
. The PR data used came from many areas where
interventions (ITNs, indoor residual spraying (IRS), etc.) have been imple-
mented so that the effect of these interventions at these locations was
included within the estimates produced by the model. This effect was not
modelled separately and cannot be extracted from our results.
The impact of Duffy negativity
. Since Duffy negative individuals are largely
refractory to
P. vivax
infection (
Miller et al., 1976
), high population fre-
quencies of this phenotype suppress endemicity, even where conditions are
