Biology Reference
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20.2.3
Ex vivo
Molecular Recognion for Early Cancer Detecon
Several emerging nanodevices can provide rapid and sensitive detection of
cancer-related molecules by enabling detection of biomolecular changes in
diseased states. It is increasingly evident that the single-molecule detection
sensitivities of nanodevices hold tremendous advantages for early detection
of cancer—a critical step in improving cancer treatment. Miniaturization of
such diagnostic tools, as in the case of nanocantilevers and nanowires, also
enables possible screening for multiple cancer markers on a single device,
thereby allowing cancer screening being faster and more cost-eficient.
(a)
(b)
(c)
Figure 20.5.
Scheme illustrating hybridization of different oligonucleotides fun-
ctionalized over each cantilever. (a) Differential signal is set to zero. (b) Hybridization
of irst (black) complementary sequence resulting in increased differential signal,
x.
(c) Second oligonucleotide (cyan)-functionalized cantilever bent because of binding
of second matching oligonucleotide (magenta).
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