Biology Reference
In-Depth Information
Table 12.1 Summary of tadpole microarray studies (21 publications)
—
cont'd
Genes/pathways
(upregulated, downregulated)
Tissue/species
Stages, conditions
No. of genes
Platform
References
Brain/
X. laevis
NF53/4,
1nM
T3, 500 nM PCB,
4 days
526 T3 genes
affected by PCB
Enriched GO terms: growth,
brain development, cell
proliferation, cell adhesion,
neuron differentiation,
apoptosis
Agilent oligoarray,
43,803 elements
Ishihara et al.
(2011)
Hind brain/
X.
laevis
NF53, recover from
cut spine,
3 days—202,
7 days—331,
21 days—275,
50% up and
down
72 annotated induced genes
associated with recovery:
transcription factors,
membrane proteins,
intracellular signaling,
coregulators. Top 4 genes:
SOCS2, XER81, neurotensin,
MORC3
Affymetrix, 29,900
elements
Gibbs et al.
(2011)
1mM
MMI, 3, 7, 21 days
Body skin/
X. laevis
NF54/55, 5 nM
T3; 0, 1, 3, 5, 7 days
240 up,
161 down
Genes: stromelysin-3,
collagenase, TH/bZIP, adult
keratin,
larval keratin
,
Genes
17-20
. Functional groups:
transcription, proteolysis at
1 day, cell cycle at 3 days,
defense response at 7 days
Affymetrix, 14,400
elements
Suzuki et al.
(2009)
