Biomedical Engineering Reference
In-Depth Information
FIGURE 6.9: (See color insert.) Modeling interference in the production of
either arachidonic acid (k
a
= v
c
= 0) and nitric oxide (k
n
= v
ca
= 0). (A)
3D view of cell position at t = 6 h for the two cases. Red dot represents the
VEGF source. Contour plots showing the final intracellular calcium profile in
(B) z = 1 m plane and (C) y = 50 m plane. Calcium concentration has
been pseudocolor-scaled so that the maximum value is red. (D) Evolution in
time of cell directional velocity v
x
. (E) Ca
2+
concentration profiles at the end
of migration, t = 6 h, along cell x-cross-section of the z = 1 m plane from the
trailing edge to the leading edge of the polarized cell. Higher Ca
2+
accumu-
lations are again observed in the thin pseudopodium, even if with decreased
maximal amplitudes. Negligible calcium events are seen in the central-nuclear
area (< 0.5 M). Mean over 10 simulations; the error bars represent standard
deviation.
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