Biomedical Engineering Reference
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with the exclusion of either AA or NO production, the spatial propagation of
calcium responses appears relatively unchanged w.r.t. the standard parameter
setting, while the peaks have a lower amplitude (i.e., 1.1 M in the case
of AA inhibition and 1.6 M in the case of NO inhibition) and the total
intracellular amount a significant decrement as well (i.e., c
(t = 6 h) 1.2
in the case of AA inhibition and c
(t = 6 h) 1.6 in the case of NO inhibi-
tion), as shown in Figure 6.9(B-C-E). Taken together the results in Figures
6.8 and 6.9 confirm the ecacy of two families of anti-angiogenic compounds,
that target different calcium-dependent mechanisms involved in cell migration
(i.e., either directly the fluxes through PM channels or the dynamics of the
second messengers).
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