The Circadian Clock in Cancer Development and Therapy - Progress in Molecular Biology and Translational Science - page 267

144. Liu G, McDaniel TK, Falkow S, Karlin S. Sequence anomalies in the Cag7 gene of the
Helicobacter pylori pathogenicity island. Proc Natl Acad Sci USA . 1999;96

(12):7011-7016.
145. Donehower LA, HarveyM, Slagle BL, et al. Mice deficient for p53 are developmentally
normal but susceptible to spontaneous tumours. Nature . 1992;356(6366):215-221.
146. Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptacek LJ. Modeling of a human circadian
mutation yields insights into clock regulation by PER2. Cell . 2007;128(1):59-70.
147. Toh KL, Jones CR, He Y, et al. An hPer2 phosphorylation site mutation in familial
advanced sleep phase syndrome. Science . 2001;291(5506):1040-1043.
148. Gu X, Xing L, Shi G, et al. The circadian mutation PER2(S662G) is linked to cell cycle
progression and tumorigenesis. Cell Death Differ . 2012;19(3):397-405.
149. Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates
leptin-regulated bone formation. Cell . 2005;122(5):803-815.
150. Maronde E, Schilling AF, Seitz S, et al. The clock genes Period 2 and Cryptochrome 2
differentially balance bone formation. PLoS One . 2010;5(7):e11527.
151. Yang X, Wood PA, Ansell CM, et al. Beta-catenin induces beta-TrCP-mediated
PER2 degradation altering circadian clock gene expression in intestinal mucosa of
ApcMin/ mice. J Biochem . 2009;145(3):289-297.

152. Wood PA, Yang X, Taber A, et al. Period 2 mutation accelerates ApcMin/

þ

þ

tumorigenesis. Mol Cancer Res . 2008;6(11):1786-1793.
153. Miyazaki K, Wakabayashi M, Hara Y, Ishida N. Tumor growth suppression in vivo by
overexpression of the circadian component, PER2. Genes Cells . 2010;15(4):351-358.
154. van der Horst GT, Muijtjens M, Kobayashi K, et al. Mammalian Cry1 and Cry2 are
essential for maintenance of circadian rhythms. Nature . 1999;398(6728):627-630.
155. Zheng B, Albrecht U, Kaasik K, et al. Nonredundant roles of the mPer1 and mPer2
genes in the mammalian circadian clock. Cell . 2001;105(5):683-694.
156. Tanioka M, Yamada H, Doi M, et al. Molecular clocks in mouse skin. J Invest Dermatol .
2009;129(5):1225-1231.
157. Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol . 2012;75:685-705.
158. Cotta-Ramusino C, McDonald 3rd ER, Hurov K, Sowa ME, Harper JW, Elledge SJ.
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting
protein required for ATR signaling. Science . 2011;332(6035):1313-1317.
159. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles
in the suprachiasmatic circadian clock. Nat Neurosci . 2007;10(5):543-545.
160. Bertolucci C, Cavallari N, Colognesi I, et al. Evidence for an overlapping role of
CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol .
2008;28(9):3070-3075.
161. Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR. Differential
functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron .
2001;30(2):525-536.
162. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM.
A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron .
2006;50(3):465-477.
163. Asher G, Schibler U. A CLOCK-less clock. Trends Cell Biol . 2006;16(11):547-549.
164. Spengler ML, Kuropatwinski KK, Comas M, et al. Core circadian protein CLOCK is a
positive regulator of NF-kappaB-mediated transcription. Proc Natl Acad Sci USA .
2012;109(37):E2457-E2465.
165. Antoch MP, Song EJ, Chang AM, et al. Functional identification of the mouse circa-
dian Clock gene by transgenic BAC rescue. Cell . 1997;89(4):655-667.
166. Lin KK, Kumar V, Geyfman M, et al. Circadian clock genes contribute to the regu-
lation of hair follicle cycling. PLoS Genet . 2009;5(7):e1000573.