The Circadian Clock in Cancer Development and Therapy - Progress in Molecular Biology and Translational Science - page 239

Cyclin D and p21 WAF1/CPI1

Per2 mutant
( Per2 S662G )

Shortened period
and phase-advance
rhythm

Cancer prone 146, 148

Per1 , Per2
double
knockout

Arrhythmic Premature aging, cancer prone,

and metabolic syndrome

AP1, ATM, c-MYC, Cyclin
D1, Cyclin E, MDM2, and
p53

29, 149, 167

Rev-erb Rev-Erba -null Shortened period Metabolic syndrome and

immune deficiency

CCL2, CXCL6, CXCL11,
IL-6, IL-19, and IL-10

9, 184

Rev-Erba ; Rev- Arrhythmic Metabolic syndrome POR, PPAR a , and SCO2 9

erbb double

knockout

Rora Rora

TUB a 8 and RASD1

-null Shortened period Metabolic syndrome and

cerebellar ataxia

10