Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 37

Furosemide 663/2.82 Liver 2700/3.43 (rat, oral), 800/2.9 9

(rat, i.p., i.v.), 2200/3.34 (mouse,
oral), 308/2.49 (mouse, i.p.),
2000/3.3 (dog, oral), 800/2.9
(rabbit, oral), 400/2.6
(rabbit, i.v.)

Teratogenesis, liver, kidney

Chlorothiazide 592/2.77 No obvious toxicity 10000/4 (rat, oral), 1386/3.14 (rat,

i.p.), 200/2.3 (rat, i.v.), 8000/3.9
(mouse, oral), 1400/3.15
(mouse, i.p.), 940/2.97
(mouse, i.v.), 1000/2
(dog, i.v.)

Skin and respiratory irritant

Copper sulfate 2/0.3 Liver, kidney, pancreas,

teratogenic

50/1.7 (mouse, oral), 300/2.48
(rat, oral)

Kidney, liver, teratogenic

Geldanamycin 3.13/0.49 Liver 1.0/0 (mouse, i.p.) Liver

AZT (3 0 -azido-
3 0 -deoxythymidine)

1068/3.02 Teratogenic, liver 750/2.88 (rat, i.v.), 3000/3.48

(mouse, i.v.)

Carcinogenic, bone marrow
depression, reproductive and
teratogenic, immunotoxic, liver,
kidney

17b-Estradiol 5.4/0.73 Teratogenic 1.2/0.08 (rat, i.m.) Carcinogenic, bone marrow

depression, teratogenic

Mifepristone 6.45/0.81 Heart, liver 5000/3.7 (rat, oral) Thrombotic effect, heart, induce

abortion

Retinoic acid ( trans ) 0.03/-1.52 Teratogenic, liver,

gastrointestinal

78/1.89 (rat, i.v.) Carcinogenic, teratogenic, liver

Coumarin 102.2/2 Cardiovascular, liver 293/2.47 (rat, oral), 196/2.29

(mouse, oral), 220/2.34 (mouse,
i.p.), 242/2.38 (mouse, s.c.)

Liver

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