Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 38

Table 3.1 ( Continued )

Zebrafish Mammalian models

LC 50 /log
LC 50 (mg/L)

Compound

Target organs LD 50 /log LD 50 (mg/kg) Target organs

Succinylcholine 238.2/2.38 Muscle, heart, liver 125/2.10 (mouse, oral), 2.1/0.32

(mouse, i.p.), 7.5/0.88 (mouse,
s.c.), 0.28/-0.55 9 (mouse,
i.v.), 0.8/-0.1 (rabbit, i.v.)

Muscle, heart, liver

Dichloroacetic acid (DCA) 72/1.85 Teratogenic, liver, kidney 1500/3.17 (rat, oral), 5640/3.75

(mouse, oral), 500/2.70 (rat, i.p.)

Liver, kidney, cardiovascular

Polychlorinated
biphenyls (PCBs)

10/1 Liver, gastrointestinal 8000/3.9 (rat, i.v.), 1900/3.28

(mouse, oral)

Liver

Phenylurea
dithiocarbamate

1.5 Teratogenic, liver Unknown Liver

Trithiophene 2.7/0.43 Liver, muscle 110/2.04 (rat, i.p.) Liver

TCDD 0.032/-1.49 Cardiovascular, liver,

kidney, teratogenic,
growth inhibition,
neuronal

0.020/-1.69 (rat, oral),
0.114/-0.94 (mouse, oral)

Cardiovascular, liver, kidney,
teratogenic, neuronal

2,4-Dinitrotoluene (DNT) 23/1.4 Teratogenic, liver 268/2.4 (rat, oral), 790/2.9

(mouse, oral)

Teratogenic, carcinogenic, liver,
reproductive

Alloxan 128/2.1 Pancreas, liver, heart Unknown Pancreas