Use of Emerging Models for Developmental Toxicity Testing - Zebrafish: Methods for Assessing Drug Safety and Toxicity - page 28

Table 3.1 Comparison of Toxicity in Zebrafish and Mammalian Models

Zebrafish Mammalian models

LC 50 /log
LC 50 (mg/L) Compound Target organs LD 50 /log LD 50 (mg/kg) Target organs

Didemnin B 6.2/0.79 Developmental 4.0/0.6 (mouse, i.v.), 4.0/0.6

(rat, oral)

Kidney

Merbarone 4.7/0.67 Teratogenic, liver, kidney,

brain

55/1.74 (mouse, i.v.) Liver, kidney

Fujisawa peptide 30/1.48 Teratogenic, heart, kidney 5.1/0.7 (rat, i.v.) Lung, heart

Ecteinascidin 0.42 Teratogenic, kidney Unknown Nonspecific

4-Ipomeanol 94/1.97 Nonspecific Unknown Liver, kidney, lungs

Dexamethasone 324/2.51 Liver, gastrointestinal,

kidney

410/2.61 (mouse, i.p.), 1800/3.26
(mouse, oral)

Liver, heart, kidney,
gastrointestinal

Doxorubicin 30.3/1.51 Teratogenic, liver,

cardiovascular, kidney

21/1.35 (mouse, i.v.), 12.60/1.10
(rat, i.v.), 9.4/0.97 (mouse, i.v.)

Liver, cardiovascular

Tacrine 11.13/1.04 Teratogenic, liver 20/1.3 (mouse, i.p.) Liver

Vinblastine sulfate 90.9/1.96 Liver, gastrointestinal,

developmental

305/2.48 (rat, oral), 220/2.34
(rat, i.p.), 15/1.18 (mouse, i.v.),
560/2.75 (mouse, i.p.)

Mutagenic, bone marrow
depression, liver,
developmental

5-Fluorouracil (5-FU) 3.3/0.52 Liver, kidney 18.9/1.2 (rabbit, oral), 230/2.36

(rat, oral), 115/2.06 (mouse,
oral), 81/1.91 (mouse, i.v.)

Reproductive, liver, kidney

Staurosporine 0.012/ 1.92 Liver, kidney 16/1.2 (mouse, i.v.) Unknown

Epirubicin 16.3/1.2 Cardiac, hemorrhage 16/1.2 (mouse, i.v.), 14.2/1.15

(rat, i.v.)

Carcinogenic, mutagenic,
cardiac