Biomedical Engineering Reference
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requires further validation. Several significant challenges remain in order to establish
zebrafish as a predictive animal model for neurotoxicity, including determining
(1) sensitivity and susceptibility of zebrafish to specific compounds and general
compound classes compared to mammalian models and humans; (2) comparability of
ADME in zebrafish using delivery in fish water to ADME in humans using other
routes of administration; and (3) role of BBB, shown to be present in zebrafish by 3dpf
(McGrath and Li, 2008).
ACKNOWLEDGMENTS
This research was supported by grants from National Institutes of Health
(2R44CA83256) and National Science Foundation (OII-0548657).
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