Biomedical Engineering Reference
In-Depth Information
4 Conclusion
In the paper, we presented a novel framework that enables large-scale hemody-
namic modeling and simulations in pediatric cardiology to aid diagnostic and
therapy decision making in patients affected by congenital disease of the AV and
the aorta. The streamlined processing pipeline includes an automated approach to
segment the centerline and lumen of the aorta as well as the inlet and outlet flow
profiles over the entire cardiac cycle. CFD simulations are performed using an
embedded boundary method solved within a level-set formulation and patient-
specific anatomical and hemodynamical boundary conditions. We demonstrate
the capabilities of our framework by performing blood flow simulations on selected
patients coming from an FDA-sponsored multicenter clinical trial, COAST. The
simulations are shown to recover flow patterns specific to the corresponding
pathologies.
Acknowledgements This work has been partially funded by European Union project Sim-
e-Child (FP7 - 248421).
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