Biomedical Engineering Reference
In-Depth Information
14-15 nm
Inhalation
Subchronic/
chronic
Rats
12, 16, 24 weeks
Toxicity, biodistribution
49, 117, 381 μg/m
3
Song et al.
174
5 nm
Inhalation
Subacute
Mice
12 days, 36 days
Toxicity, dosimetry
3.3 mg/m
3
Stebounova et
al.
175
18-20 nm
Inhalation
Acute
Rats
2 weeks
Mortality, pulmonary
function
76, 135, 750 μg/m
3
Sung et al.
176
ca. 60 nm
b
Intratracheal
instillation
Acute
Rats
6 h
Platelets
0, 10, 50, 100, 250
μg/mL
Jun et al.
177
NA (aggregate:
244 nm)
Intratracheal
instillation
Subacute
Mice
1, 7, 14, 28 days
Toxicity, genotoxicity
125, 250, 500 μg/kg
Park et al.
178
29 nm
I.p. injection
Acute
Mice
24 h
Gene expression
100, 500, 1000 mg/
kg
Rahman et al.
179
10-15 nm
I.v. injection
Acute
Mice
25 min
Hematology, mortality
0, 4, 6, 8 mg/kg bw
Shrivastava et
al.
180
15-40 nm
I.v. injection
Subchronic
Rats
32 days
Hematology, biochemistry,
biodistribution
0, 4, 10, 20, 40 mg/
kg
Tiwari et al.
181
ca. 50 nm
I.v. injection
Acute
Mice
4 days
Biodistribution in pregnant
mice
0, 1.2, 2.2 mg Ag/
kg
Austin et al.
182
50-100 nm
S.c. injection
Subacute
Rats
2, 4, 8, 12, 18, 24
weeks
Accumulation in the brain
and blood-brain barrier
effects
62.8 mg/kg
Tang et al.
183
13 nm
Implantation
Acute
Mice
13 days (after
transfer)
Blastocyst development
0, 25, 50 μM
Li et al.
184
<100 nm
b
Implantation
Subchronic/
chronic
Rats
7, 14, 30, 90, 180
days
Local inflammation
NA
Chen et al.
185
Source:
Based on studies published in the scientific literature by April 2012. The studies addressing the use of nanosilver-containing dressings were excluded. A
number of studies used the same experiments to investigate different endpoints (e.g., hence same doses).
Note:
NA, data not available.
Doses are only indicated in mass unit (although not shown here, surface area and number of particle concentrations are also reported in some studies).
a
Weak or lacking documentation in the reported studies.
b
