General Animal and Aquatic Toxicity - The Toxicology of Methanol - page 76

TABLE 4.1 ( Continued )

Species LD 50 , mg/kg Comments References

Mouse 14,390 Smith and Talyor

(1982)

Mouse 7,300-1,000 Lington and Bevan

(1994)

Dog 6,300 LD80 100%

methanol

Haskell et al. (1921)

Dog 6,300 MLD50%

methanol

Leo (1927)

Dog 8,000 WHO (1997)

Dog 7,500 RTECS (1944)

Dog 2,500-9,000 One died 4 gm/kg

and
One died 9.0 gm/kg
Seven given
2.5-8.0 g/kg lived

Gilger and Potts
(1955)

Miniature pig 5,000 CNS effects, no

ocular toxicity

Dorman et al. (1993)

>

Monkey 7,000-9,000 Monkey given 5 or

6 g/kg survived
MLD 7000

Cooper and Felig
(1961)

Monkey 6,000 Four out of eight

monkeys died
following
treatment with
sodium
bicarbonate

Potts (1955)

Monkey 2,000-3,000 Acidosis, semicoma,

and
ophthalmologic

Gilger and Potts
(1955)

Rabbits 7,000 100% mortality

Rabbit 7,200 MLD Baer (1898)

Rabbits 14,200 LD 100 Munch and

Schwartze (1925)

Rabbit 14,400 LD 50 Munch (1972)

Rabbit 2,100 100% mortality Gilger and Potts

(1955)