General Animal and Aquatic Toxicity - The Toxicology of Methanol - page 75

Most of these acute oral studies are not GLP nor done to any standard
protocol, but demonstrate low acute oral toxicity. Most of the acute oral
data was previous summarized by American Methanol Institute (2001).
Table 4.1 gives a listing of available data on methanol acute oral
toxicity.

TABLE 4.1 Mortality from Single Ingestion of Methanol in Various
Animal Species
Species LD 50 , mg/kg Comments References

Rat 5,628 RETC (1994)

Rat 9,100 Welch and Slocum

(1943)

Rat 9,540 Weil (1972)

Rat 11,520 Union Carbide

(1994)

Rat 13,700 Smyth et al. (1941)

Rat 7,914 BASF (1975)

Rat 12,900 Deichmann and

Mergard (1948)

Rat 10,300 Kimura et al. (1971)

Rat 7,300 RTECS (1994)

Rat 5,065 BASF (1961)

Rat 12,750 Cornish and Adefuin

(1967)

Rat 6,200-12,900 Lington and Bevan

(1994)

Rat 9,000-9,500 Gilger and Potts

(1955)

Rat 8,300 Alder et al. (1938)

Rats
14 day 5,861 Kimura et al. (1971)

Young adults 10,300
Old adults 6,970

Mouse 5,800 Chikin and

Shadurskil (1969)
(continued )