Biomedical Engineering Reference
In-Depth Information
TABLE 8.1 Key Significant Cancer Findings in Ramazzini Foundation
Methanol Study
Sex
(Number of
Animals)
Total
Malignant
Tumors
Methanol,
(ppm)
Ear Duct
Carcinomas
Hemolymphoreticular
Neoplasias
20,000
M (100)
70
24
40
20,000
F (100)
63
19
28
5,000
M (100)
64
17
36
5,000
F (100)
48
16
24
500
M (100)
55
13
35
500
F (100)
48
8
24
0
M (100)
50
9
28
0
F (100)
43
9
13
0.01 using X
2
test.
p
<
0.05 using X
2
p
<
test.
and mesentic lymph nodes and are not found in other tissues. It is not a
common or appropriate practice to combine histiocytic sarcoma, mono-
cyclic leukemia, or myeloid leukemia with neoplasm of lymphocytic
origin as done by the Ramazzini Foundation. It should also be pointed out
that diagnosis of lesions including lymphoma and leukemia might be
difficult if disease or autolysis is a factor. In the males, the concurrent
hemolymphorecticular tumor rate is higher than the historical rate but still
TABLE 8.2 Key Significant Cancer Findings in Male Rats in Ramazzini
Foundation Methanol Study
Sex
(Number of
Animals)
Total
Malignant
Tumors
Methanol,
(ppm)
Ear Duct
Carcinomas
Hemolymphoreticular
Neoplasias
20,000
M (100)
70
24
40
5,000
M (100)
64
17
36
500
M (100)
55
13
35
0
M (100)
50
9
28
p
<
0.01 using X
2
test.
