Biomedical Engineering Reference
In-Depth Information
TABLE 8.3 Key Significant Cancer Findings in Female Rats
in Ramazzini Foundation Methanol Study
Sex
(Number of
Animals)
Total
Malignant
Tumors
Methanol,
(ppm)
Ear Duct
Carcinomas
Hemolymphoreticular
Neoplasias
20,000
F (100)
63
19
28
5,000
F (100)
48
16
24
500
F (100)
48
8
24
0
F (100)
43
9
13
p
<
0.01 using X
2
test.
p
<
0.05 using X
2
test.
within the normal historical range reported for the laboratory. No positive
dose-response relationship with a statically significant trend was
reported in males. In the females, the concurrent control hemolymphor-
ecticular tumors rate is the same as the historical control rate. Only the top
dose female rate had a statically significant increased of hemolymphor-
ecticular tumors over the control. A positive dose-response relationship
with a statically significant trend in hemolymphorecticular tumors was
TABLE 8.4 Dose-Response Trends in Ramazzini Foundation Methanol
Study
Sex
(Number of
Animals)
Total
Malignant
Tumors
Methanol,
(ppm)
Ear Duct
Carcinomas
Hemolymphoreticular
Neoplasias
20,000
M (100)
70
24
40
20,000
F (100)
63
19
28
5,000
M (100)
64
17
36
5,000
F (100)
48
16
24
500
M (100)
55
13
35
500
F (100)
48
8
24
0
M (100)
50
9
28
0
F (100)
43
9
13
p
<
0.01 Cochrane-Armitage test for dose-response relationship.
p
<
0.05 Cochrane-Armitage test for dose-response relationship.
