Biomedical Engineering Reference
In-Depth Information
NZW rabbits reveal that, similar to C3H mice, rabbits are resistant to
MeOH teratogenicity despite differences in pharmacokinetics and
MeOH metabolism between these species. There was no measurable
effect of MeOH on any developmental parameters (litter or morpho-
logical), similar to C3H mice, with both species being exposed to
similar dosing schedules during gestation (Sweeting et al., 2011)
(Figures 7.13 and 7.14).
In addition to species differences in MeOH teratogenicity, there are
also strain-specific malformations that result from MeOH exposure
during gestation (Table 7.1). Studies primarily in rodents have outlined
FIGURE 7.13 MeOH-initiated birth defects in NZW rabbits. Pregnant does
were treated i.p. with two doses of 2 g/kg MeOH (20% solution in saline) or its
saline vehicle, with an 8-hour interval, on GD 7 or 8. Does were euthanized on
GD 29 for assessment of fetuses. Fetal outcomes from GD 7 and 8 MeOH
exposures were not different (p
0.05), and these data were combined. Fetal
outcomes from GD 7 and 8 MeOH exposure were not different (p
>
0.05),
>
and these data were combined (x,y
ΒΌ
number of litters, number of fetuses).
Source: From Sweeting et al. (2011).
