Biomedical Engineering Reference
In-Depth Information
FIGURE 7.10 Six-hour MeOH and FA AUC in male mice, rabbits, and
primates following a single dose of 2 g/kg MeOH. A total of three to six mice,
three rabbits, and three primates were sampled at each time point for
treated groups. The symbol
indicates that the 6-hour MeOH AUC and
FA AUC were different from the respective mouse values. The symbol
y
indicates that the 6-hour FA AUC in primates was different from that in rabbits
(p
<
0.05). Source: From Sweeting et al. (2010).
regimen, C57BL/6J and C3H mice both exhibited pharmacokinetic
profiles similar to that in the CD-1 strain (Figure 7.11) (Sweeting et al.,
2011). Peak plasma concentrations and AUC levels were identical
between mouse strains over the initial 12-hour period of sample
collection.
Our results can be compared with other pharmacokinetic studies
performed in other species and through different routes of administra-
tion (Table 7.2). MeOH and FA peak concentrations in our mice
administered (i.p.) 20 times the dose given to rats (i.v.) were approxi-
mately 23-fold and fourfold higher, respectively, in the mice (Horton
et al., 1992). However, the MeOH clearance rates and FA AUC values
found in our mouse studies (2 g/kg MeOH i.p.) were comparable to
those found in the rat (100mg/kg MeOH i.v.). MeOH plasma concen-
tration levels in humans at which toxicity is observed have not been
