Biomedical Engineering Reference
In-Depth Information
Battelle (2006): Human vs mouse at steady-state
100,000
10,000
Human
1000
Mouse
100
10
1
Human/mouse ratio
0.1
0.01
1
10
100
1000
10,000
Air (ppm)
FIGURE 6.1 Battelle (2006) model-predicted mouse and human steady-
state venous blood methanol concentrations versus airborne methanol con-
centration for continuous inhalation exposure. Also depicted is the ratio of
predicted steady-state human and mouse blood concentrations.
Battelle (2006) model-predicted human and mouse steady-state values
diverge markedly, and the maximum difference, an approximately
3.5-fold factor (367mg/l vs 106mg/l), is reached at 875 ppm, after
which the ratio of Battelle (2006) model-predicted human to mouse
blood concentrations begins to decline again. At 10,000 ppm and
higher airborne methanol concentrations, the predicted differences
are again less than 10%.
The present analysis thus implies that the Battelle (2006) model-
predicted human steady-state blood methanol concentrations are always
greater than the corresponding mouse concentrations, with the greatest
differences occurring in the vicinity of 1000 ppm, the Rogers et al. (1993)
NOEL level, where the Battelle model-predicted human steady-state
concentration is about 3.4-fold higher than the corresponding mouse
concentration (521 mg/l vs 154mg/l). Assuming that there are no pharma-
codynamic differences between mice and humans, these Battelle (2006)
