Biomedical Engineering Reference
In-Depth Information
TABLE 6.2 Mouse and Human Blood Methanol Concentrations (mg/l)
Predicted by the Battelle (2006) and Bouchard et al. (2001) Models at
Steady State for Various Airborne Methanol Concentrations (ppm)
Methanol
in Air,
(ppm)
Battelle
Mouse,
(mg/l)
Battelle
Human,
(mg/l)
Ratio:
Bat H /
Bat M
Bouchard
Human,
(mg/l)
Ratio:
Bat H /
Bou H
1
0.0213
0.0226
1.060
0.0313
0.722
10
0.216
0.229
1.063
0.313
0.732
50
1.134
1.213
1.069
1.565
0.775
100
2.429
2.622
1.079
3.130
0.838
250
7.685
8.766
1.141
7.825
1.12
500
25.78
41.17
1.597
15.65
2.63
525
28.71
49.13
1.711
16.43
2.99
550
31.91
56.98
1.786
17.22
3.31
575
35.4
71.07
2.008
18.00
3.95
600
39.22
85.69
2.185
18.78
4.56
625
43.36
103.0
2.374
19.56
5.26
675
52.71
144.9
2.749
21.13
6.96
750
69.56
221.5
3.184
23.48
9.44
875
106.0
367.0
3.463
27.39
13.4
1,000
153.9
520.9
3.385
31.30
16.6
2,000
980.3
1,798.0
1.834
62.60
28.7
5,000
4,681.2
5,663.3
1.210
156.5
36.2
10,000
11,061.3
12,110.4
1.095
313.0
38.7
Also shown are ratios of Battelle (2006) model-predicted human to Battelle (2006)
model-predicted mouse blood methanol concentrations (Bat H / Bat M), and Battelle
(2006) model-predicted human to Bouchard et al. (2001) model-predicted human blood
methanol concentrations (Bat H / Bou H). See also Figures 6.1 and 6.2
the ratio of the Battelle (2006) model predicted steady-state human
and mouse blood concentrations as a function of airborne methanol
concentration.
At no airborne methanol concentration is the Battelle (2006) model-
predicted steady-state human blood methanol concentration smaller
than the corresponding mouse concentration, but the differences are
less than about 10% below 250 ppm. However, above 250 ppm the
