Biomedical Engineering Reference
In-Depth Information
(CAB and CVB, respectively) as well as the airborne methanol con-
centration (CCh) entirely in terms of fixed PBPK model parameters and
the steady-state concentration of methanol in the venous blood leaving
the liver (CVL). At steady state, the latter quantity is the same as C
max
in the Battelle (2006) model, and AUC
C
max
. Thus, any infer-
ences that can be drawn regarding species sensitivity differences in
C
max
apply equally to 24-hour AUC at steady state.
The final human and mouse parameter values from the “visual
optimization” employed by Battelle are reproduced in Table 6.1 (see
“Mouse” and “Human” columns). These values were utilized in
computing steady-state mouse and human venous blood methanol
concentrations with the steady-state PBPK model equations
described earlier. Results of these computations are presented in
tabular form (Table 6.2) and graphically in Figure 6.1. Also shown is
¼
24
TABLE 6.1 Battelle (2006) PBPK Model Parameter Values. Human
Metabolism Parameters That were Changed in the Modified Battelle
Human Model are Italicized
Model Parameter
Mouse
Human
Modified Human
bw, kg
0.03
70
70
bw
0.75
0.072084
24.20045
24.20045
V
max
, mg/h
1.030806
266.205
6980.156
V
max2
, mg/h
1.369603
0
0
K
m
, mg/l
12
12
460
K
m2
, mg/l
210
0
0
QC, l/h
1.830942
447.7084
447.7084
QL, l/h
0.457736
101.6298
101.6298
QF, l/h
0.091547
23.28084
23.28084
QR, l/h
1.28166
322.7978
322.7978
kL, /h
0.
0.015212
0.015212
VVB, kg
0.001104
4.151
4.151
QP, l/h
1.830942
447.7084
447.7084
Fracin
0.73
0.75
0.75
PB
1350
1626
1626
