Biomedical Engineering Reference
In-Depth Information
weight gain, and slight liver effects as treatment related effects. More
information about chronic exposure of rodents to methanol is found in
Chapter 8 on cancer. Developmental effects in rodents are found in
Chapter 5. Interesting, effects were seen in repeat exposure rodent
studies; above the acute lethal dose in humans (
1000mg/kg) suggesting
that repeat exposure data in rodents have limited relevance to humans.
The chapters in this topic address the key methanol issues of
metabolism in animals, reproductive and developmental results in
rodents, and the potential issue of cancer in rodents. The other chapters
help the understanding of the key issues in animal toxicity of methanol
and how it relates to humans.
REFERENCES
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American Methanol Intstitute (2001) High production Volume Program on
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Andrews, L.S., Clary, J.J., Terrill, J.B., and Bolte, H.F. (1987) Subchronic
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BASF AG. (1961) unpublished data cited by American Methanol Institute
(2001) in High production Volume Program submission to USEPA 66p.
BASF AG. (1975) unpublished data cited by American Methanol Institute
(2001) in High production Volume Program submission to USEPA 66p.
BASF AG. (1979) unpublished data cited by American Methanol Institute
(2001) in High production Volume Program submission to USEPA 66p.
BASF AG. (1980) unpublished data cited by American Methanol Institute
(2001) in High production Volume Program submission to USEPA 66p.
