A Genomic View of Secondary Metabolite Production in Cyanobacteria - Advances in Botanical Research - page 213

Figure 6.11 Selected aer gene clusters identiied in diferent cyanobacteria. See the
colourplate.
Figure 6.12 ProposedbiosynthesisoftheChoiresidueandofaeruginoside126A.The
domainabbreviationsaredeinedintheabbreviationslist.
4.2.2. Microginins
Microginins are linear PK/NRP isolated from Microcystis or Plankto-
thrix species. They bear a β-amino acid in the N-terminal position, the
3-amino-2-hydroxy-decanoate (Ahda) ( Welker & von Dohren, 2006 ).
Several variants have been detected. These peptides are inhibitors of the
angiotensin-converting enzyme. The cluster responsible for the biosynthesis
of microginins in P. rubescens NIVA CYA-98 has been identified and called
the mic cluster ( Rounge et al., 2009 ). It consists of four genes, three coding
for NRPS or PKS/NRPS hybrid, and one ABC transporter. Experimental
evidences for the cluster function and the enzyme functions are lacking.
4.2.3. Cyanopeptolins
Cyanopeptolins are cyclic nonribosomal depsipeptides containing a lac-
tone bond. They are produced by cyanobacteria of different genera such as