Gene Delivery Using Chemical Methods - Challenges in Delivery of Therapeutic Genomics and Proteomics - page 164

NH 2

CH 3

O

N +

N

H 3 C

O

F

NH 2

CH 3

O

N +

N +

H 3 C O

H 3 C

G

NH 2

O

NH

O

CH 3

N +

N

H 3 C O

H

O

H 2 N

N CH 3

N +

CH 3

CH 3

N +

CH 3

N

H 2 N

O

I

Figure 4.16 Chemical structures of cationic lipids containing quaternary ammonium salt and
lipoamines II.

SMC, 3LL Lewis lung, and CaCO 2 colon carcinoma cell lines [242] . In another
study, the same group has introduced cyclic guanidine-based moieties in lipopoly-
amine to obtain compounds of either linear or globular polar head groups [243] . In
another strategy, amidinium moiety was introduced in the form of arginine amino
acid [244] . This compound, K ( Fig. 4.17 ) coformulated with DOPE, demonstrated