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O
CH
3
O
O
H
2
N
N
CH
3
HN
O
ADPDE
O
CH
3
O
O
H
2
N
N
CH
3
HN
O
ADODE
H
2
N
CH
3
H
2
N
NH
NH
O
HN
O
O
NH
N
N
O
H
O
CH
3
NH
2
J
CH
3
NH
H
2
N
HN
O
H
N
N
H
2
N
O
CH
3
K
Figure 4.17
Chemical structures of amidinium salt lipids and miscellaneous cationic entities I.
transfection efficiency similar to Lipofectin
TM
and DC-Chol using -galactosidase
plasmid injected intradermally into Swiss Webster mice.
Bis(guanidinium)-tren-cholesterol (BGTC) prepared by combining bis-guani-
dinium with cholesterol, (
Fig. 4.18
) proved to be an effective transfection vector in
eukaryotic cells
[245]
. Subsequently, the same group has demonstrated an
in vivo
transfection activity
[246]
. Solodin explored the concept of introducing nitrogen-
containing heterocyclics in the structure of the lipidic vector and came up with sev-
eral imidazolium-based cationic lipids
[247]
. Exploring this direction further, a series
of low-toxic imidazolium derivatives were synthesized, which were evaluated in
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