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Scheme 11
candidate vaccines elicited significant rises in mean anti-LPS IgG levels
in a clinical trial with adult volunteers (Scheme 11).
115
S. flexneri, which has 14 serotypes and subtypes, is endemic in de-
veloping countries and is the most frequently isolated species worldwide.
The predominant serotypes are Sf2a, followed by 1b, 3a, 4a and 6. The
structure of the repeating unit of PS from Sf2a LPS is represented by
formula 32. Mulard's group performed the synthesis of fragments having
up to 3 RU of Sf2a PS.
116
The TT-conjugate of a synthetic pentadeca-
saccharide 33 (3 RU) elicits a better serum anti-polysaccharide response
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