Metabolic Interactions of Pesticides - Pesticide Biotransformation and Disposition - page 152

Table 7.2 (Continued)
Inducer and/or substrate

Species Effect Reference

Dieldrin Dog Increased metabolism in vitro of chlorfenvinphos Wright et al. (1972)

Dieldrin Rat Increased metabolism in vitro of chlorfenvinphos Wright et al. (1972)

Dieldrin Rat Increased metabolism in vitro of estradiol-17β Welch et al. (1971)

Dieldrin Mouse Increased metabolism in vitro of chlorfenvinphos Wright et al. (1972)

Mirex Mouse/rat Increased O-demethylation in vitro of p -nitroanisole

and CYP content

Baker et al. (1972)

Mirex and kepone Rat Increased warfarin hydroxylation in vitro and increased

CYP content

Kaminisky et al. (1978)

Mirex and kepone Gerbil Increased benzo( a )pyrene hydroxylase activity in vitro

and increased CYP content

Crouch and Ebel (1987)

Mirex and kepone Mouse Increased acute in vivo hepatotoxicity; mirex had

greater effect

Fouse and Hodgson (1987)

Increased CYP and N - and O - dealkylation in vitro Fabacher and Hodgson (1976)

Induction of CYP2B10, 1A2, and 3A Lewandowski et al. (1989)

Methoxychlor Rat Increase in total CYP and gender-dependent increases

in CYP 1A1- and 1A2-related activities

Orepeza-Hernandez et al. (2003)

Increase in CY2PB and CYP3A Li et al. (1995)

ORGANOPHOSPHORUS INSECTICIDES
3-Methylcholanthrene Rat Increased metabolism in vitro of azinphosmethyl to a

cholinesterase inhibitor

Murphy and DuBois (1957)

Phenobarbital Rat/mouse Decreased in vivo toxicity of parathion, methyl

parathion, demeton, disulfoton, azinphosmethyl,
dioxathion, ethion, carbophenothion, mevinphos, and
EPN

Dubois (1969)

Malathion Rat Increased CYP Matthews and Devi (1994)

S,S,S-tri- n -butyl
phosphorotrithioate

Hen Increased CYP Lapadula et al. (1984)

Chlorpyrifos Human Increased CYP isoforms in hepatocytes Das et al. (2008a,b)

CARBAMATE INSECTICIDE
Carbaryl Chicken Pentobarbital sleep time decreased Puryear and Paulson (1972)