Metabolic Interactions of Pesticides - Pesticide Biotransformation and Disposition - page 151

DDT Human Increased metabolism, in vitro, of EPN and

p -nitroanisole; increase in CNS arousal with
phenobarbital administration

Rappolt (1973)

DDT and analogs Mouse Increased P450 levels, aniline hydroxylase activity,

zoxazolamine paralysis time, and hexobarbital sleep time;
QSAR for 28 analogs

Abernathy et al. (1971a,b)

Diphenyl hydantoin Rat DDT and DDE storage decreased, in vitro DDT

metabolism increased

Cranmer (1970)

o,p -DDD Guinea pig Phenobarbital sleep time decreased, in vitro

phenobarbital metabolism increased

Straw et al. (1965)

p,p -DDD Rat Increased metabolism in vitro of estradiol-17β Welch et al. (1971)

o,p -DDT Rat PXR- and CAR-dependent increase in CYPs 2B2 and

3A2

Kiyosawa et al. (2008)

o,p -DDT HepG2

cells

Increase in CYP3A4 mRNA Medina-Diaz and Elizondo (2005);

Medina-Diaz et al. (2007)

p,p -DDE Rat Increased metabolism in vitro of estradiol-17β Welch et al. (1971)

Induction of CYP 2b 3A Wyde et al. (2003)

Chlordane Rat In vitro metabolism of hexobarbital, aminopyrine, and

chlorpromazine unchanged after one dose; all increased
after three doses

Hart and Fouts (1963)

Chlordane Dog Decreased toxicity of dicoumarol Welch and Harrison (1966)

Increased metabolism in vitro of estrone Welch et al. (1971)

Lindane Rat Increased metabolism in vitro of estradiol-17β Welch et al. (1971)

Increased expression of mRNA for CYP1A1, 1A2, 2B1,
2B2, and 2E1 as well as associated catalytic activities

Johri et al. (2003, 2008)

Heptachlor Rat Increased metabolism in vitro of estradiol-17β Welch et al. (1971)

Toxaphene Rat Increased metabolism in vitro of estradiol-17β Welch et al. (1971)

Increased detoxication of EPN, O-demethylation of
p -nitroanisole and N-demethylation of aminopyrine

Kinoshita et al. (1966)

Dieldrin Rhesus

monkey

Increased metabolism in vitro of chlorfenvinphos Wright et al. (1972)

( Continued )