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were tested in laboratory assays against the representative species of major
groups of fouling organisms, viz . bacteria, fungi, diatoms, the spores and zy-
gotes of macroalgae and the blue mussels Mytilus edulis . Several components
showed promising levels of the activity. Especially, two diketonyl diterpenes
( 345, 3410 ) showed almost the same bioassays of antibacterial and antifun-
gal activities as those of TBTO and also showed almost the same minimum
inhibitory concentration of 8
gmL -1 for marine bacteria and marine fungi
with those of TBTO, and elegandiol ( 344 ) showed high bioassay activities
for the inhibition of microalgal growth, and the development of macroalgal
spores and zygotes [16].
Three renillafoulins 3411 - 3413 from the Atlantic sea pansy Renilla reni-
formis , inhibited barnacle settlement with EC 50 values ranging from 0.02
to 0.2
µ
gmL -1
µ
[17, 27]. Renillafoulins and pukalide 3418 isolated from oc-
Fig. 2 Chemical formulae of diterpenes isolated from Bifurcaria bifurcata [16]
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