Biomedical Engineering Reference
In-Depth Information
Alfentanil
Multiple
0.01e0.06 mg/
kg/h i.v.
<
30 min
Used as an adjunct to general anesthesia, i.e. co-
administer a volatile agent or continuous infusion of
propofol/alphaxalone
Mechanical ventilation likely to be required at higher
infusion rates
Sufentanil
Macaque
6e30
g/kg/hr
1e2 h
Used as an adjunct to general anesthesia, i.e. co-
administer a volatile agent or continuous infusion of
propofol/alphaxalone
Mechanical ventilation required
m
i.v.
Local Anesthetics
Lidocaine
Multiple
4 mg/kg tissue
infiltration (toxic
dose
Onset 1e2 min;
duration 1.5e2h
Can be diluted 1 in 2 to increase accuracy of dosing
in smaller primates
10 mg/kg
in other species)
>
Bupivacaine
Multiple
1e2 mg/kg tissue
infiltration (toxic
dose
Onset 5e10 min;
duration 4e12 h
Can be diluted 1 in 2 to increase accuracy of dosing
in smaller primates
4 mg/kg
in other species)
>
Levobupivacaine
Multiple
0.5e1.5 mg/kg
tissue infiltration
(toxic dose
Onset and
duration similar
to bupivacaine
Can be diluted 1 in 2 to increase accuracy of dosing
in smaller primates
>
5 mg/kg)
p.o.
intravenous
Doses are based on the authors' experience and published data (
Dobromylskyj et al., 2000; Olberg, 2007; Sleeman 2007; Popilskis et al., 2008
) and provided as a general guide only.
¼
per os.,s.c.
¼
subcutaneous, i.m.
¼
intramuscular, i.v.
¼
