Biomedical Engineering Reference
In-Depth Information
TABLE 17.7
Analgesic Doses for Use in Nonhuman Primates
Drug
Species
Dose
Duration
Comments
Nonsteroidal Anti-inflammatories
Co-administration of gastroprotectants may be
beneficial
Carprofen
Multiple
2e4 mg/kg s.c.,
i.m.
24 h
Dosing frequency can be increased for 2e3 doses if
required
Meloxicam
Multiple
0.1 mg/kg p.o.,
s.c.
24 h
May be administered for at least up to 4e5daysif
needed
Dosing frequency can be increased for 2e3 doses if
required
Macaque
0.2 mg/kg p.o.,
s.c.
24 h
Opioid agents
Buprenorphine
Multiple
0.005e0.03 mg/
kg s.c., i.m., i.v.
6e12 h
High doses (0.01e0.03 mg/kg) may lead to sedation
and/or respiratory depression
Morphine
Multiple
0.1e2 mg/kg s.c.,
i.m.
3e6 h
Used as an adjunct to general anesthesia, i.e. co-
administer a volatile agent or continuous infusion of
propofol/alphaxalone
Sedation and respiratory depression may be
problematical (esp. at higher doses)
Can be antagonized by buprenorphine 0.01 mg/kg
i.m., i.v. (nonemergency) or naloxone (
Table 17.4
)
(emergency)
Fentanyl
Multiple
5e10
g/kg i.v.
1e2 h
Used as an adjunct to general anesthesia, i.e. co-
administer a volatile agent or continuous infusion of
propofol/alphaxalone
Sedation and respiratory depression may be
problematical (esp. at higher doses)
Can be antagonized by buprenorphine 0.01 mg/kg
i.m., i.v. (nonemergency) or naloxone (
Table 17.4
)
(emergency)
m
bolus
10e25
g/kg/h
continuous
infusion
m
