Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications - LC-MS in Drug Bioanalysis - page 289

IT Ion trap

lin range Linear range

LLE Liquid-liquid extraction

log P Logarithm of octanol/water partition coef fi cient

MeOH Methanol

Me-O- t Bu Methyl- tert butyl ether

MeS Methylscopolamine

MRM Multiple reaction monitoring

MS Full scan mass spectrometry

MS/MS Tandem mass spectrometry, product ion scan

MW Mono-isotopic molecular weight

n.s. Not speci fi ed

OAc Acetate

OP Organophosphorus compound

QqQ Triple quadrupole mass spectrometer

QTA Quaternary tropane alkaloid

ref Reference

Sat Satropane

Scp Scopolamine

SIM Selected ion monitoring

Solv HPLC solvent

SPE Solid-phase extraction

SQ Single quadrupole mass spectrometer

T Temperature

TA Tropane alkaloid

Tio Tiotropium

Trop Tropisetron

Tros Trospium

TSP Thermospray

TTA Tertiary tropane alkaloids

WHO World Health Organisation

α 1-AR a 1-Adrenoreceptor

a 7-nAChR a 7-Nicotinic receptor

1 Introduction

The present topic chapter presents an actual summary on the use of LC-MS-based
procedures applied to mammalian samples for qualitative and quantitative analysis
of tropane alkaloids (TA). Relevant literature obtained from PubMed database
search and references cited therein is summarized and commented to provide an
overview on various natural TA structures and their related pharmaceutical deriva-
tives. A comprehensive unique set of TA was compiled that is categorized by diverse
fields of analytical applications.