Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications - LC-MS in Drug Bioanalysis - page 288

analysis are pointed out. At least diverse fields of applications are categorized to
review several examples of PK, distribution, and biotransformation studies as well
as toxicological analysis. Concluding remarks point out potential future trends and
possibilities of LC-MS in clinical pharmacology.

Abbreviations

5-HT 3 R 5-Hydroxytryptamine (serotonin) receptor

ACN Acetonitrile

Ada Anisodamine

Adi Anisodine

AGP Alpha-glycoprotein

APCI Atmospheric pressure chemical ionization

API Active pharmaceutical ingredient

Atr Atropine

AtrE Atropinesterase

BBB Blood-brain barrier

Becg Benzoylecgonine

Beme Bemesetron

Benz Benztropine

BuS N -butyl-scopolamine

CID Collision-induced dissociation

Cim Cimetropium

CNS Central nervous system

Coc Cocaine

COPD Chronic obstructive pulmonary disease

Da Dalton

EBQ 1 Q 2 Double focusing sector fi eld mass spectrometer

EE Ethylacetate

ESI Electrospray ionization

Et 2 O Diethylether

FA Formic acid

FAB Fast atom bombardment

GIT Gastrointestinal tract

glucu Glucuronide conjugate

Gran Granisetron

Hep-SA Heptanesulfonic acid

HPLC High-performance liquid chromatography

hyo Hyoscyamine

IBS Irritable bowel syndrome

Ipra Ipratropium

iso Isocratic