Biomedical Engineering Reference
In-Depth Information
Table 2
(continued)
Author
Matrix
Sample [mL]
Drugs
IS
“Work Up”
Stationary phase
Mobile phase
Detection mode
Validation data
Ref.
Hasselstrom
et al.
Serum
0.06
Clozapine, quetiapine,
ziprasidone
Clozapine-d3, quetiapine-
d8, ziprasidone-d8
Zinc sulfate, MeOH,
96-well plate
Zorbax SB-C8
(2.0
×
50 mm,
1.8 m m)
Gradient with formic
acid in water and
formic acid in
MeOH
ESI, positive mode,
MS/MS, MRM
Selectivity,
recovery, ion
suppression,
LLOQ,
precision,
trueness, LT
stability,
processed
sample
stability
[
46
]
IS
internal standard,
SPE
solid phase extraction,
LLE
liquid-liquid extraction,
MTBE
methyl-
t
-butyl-ether,
MeOH
methanol,
EtOH
ethanol,
PrOH
propanolol,
APCI
atomic
pressure chemical ionization,
LLOQ
lower limit of quantification,
F/T
freeze-thaw,
LT
long-term
